High levels of it have been repeatedly correlated with disease severity in cancer.24, 25 Circulating IGFBP2 has demonstrated as a candidate marker for predicting the cancer prognosis including that of gastric cancer.26 In lung cancer, overexpressed IGFBP2 enhances cell activity and chemoresistance by enhancing autophagy.27 However, while IGFBP2 is a candidate target with therapeutic mechanism in cancer,28 its role in the progression of BC is still unclear. This evidence concerns the gene IGFBP2 and breast cancer.