Emerging investigations have implied the carcinogenic function of MYBL2 in cancer progression,32 and it was also reported as a transcription factor in LUAD.33 Our study revealed that MYBL2 was targeted by miR‐423‐5p and LOXL1‐AS1 regulated the expression of MYBL2 by completely sponging miR‐423‐5p. Here, PTGDR is linked to cancer.