In this context, and in agreement with previous studies, we recently reported that signalling induced by VEGFR‐1 activation further stimulates tumour invasiveness and results in ERK phosphorylation.8, 30, 42, 43 This receptor has been also correlated to cell survival and chemoresistance.3, 10, 11, 44 Moreover, increased VEGFR‐1 expression and/or up‐regulation of its specific ligand PlGF are considered mechanisms of tumour resistance to VEGF‐A targeting anti‐angiogenic therapies.45, 46, 47, 48. This evidence concerns the gene VEGFA and neoplasm.