The expression of HLA class I and class II molecules and APM has been investigated in CSCs/CICs isolated from colorectal cancer (CRC) and glioblastoma multiforme (GBM) showing an overall aberrant expression of these molecules, with, in some cases, failure in their modulation by the pre-treatment with IFNs (both alpha and gamma) or DNA demethylating agent (5-Aza CdR) [64, 65]. Here, ANPEP is linked to glioblastoma.