KCNA1 and breast adenocarcinoma: The suggestion that the increased mRNA expression of Kv1.1 and Kv1.3 is secondary to decreased DNA methylation at the DNA sequences of these genes is consistent with the results of a previous study that had reported that increased DNA methylation at the Kv1.3 gene promoter region was associated with decreased Kv1.3 mRNA levels in breast adenocarcinoma [61].