APOB and type 2 diabetes mellitus: However, another way to view lipid-associated risk in T2DM stems from genetic evidence from Ference et al. In their recent work, they compared the association of triglyceride-lowering LPL variants and LDL-C–lowering LDLR variants with the risk of CVD per unit difference in Apo B, to demonstrate that reducing both TG and LDL-C variants was associated with lower CHD risk per unit lower level of Apo B-containing lipoproteins [12].