BRD4 and bacterial infectious disease: Blockage or knock-down of CDK9 in monocytes reduced inflammatory responses to anaerobic P. gingivalis, a result of dampened transcription in the gene promoters, similar dampened innate immune responses in the bacterial infection has been reported in Brd4 blockage by BET inhibitor I-BET40,41 or conditional knock-out of Brd4 in myeloid-lineage cells42, and topoisomerase 1 inhibition16.