During this epileptogenic process, the MCs survived and there was an upregulation of Shh and Smo. In more severe epilepsy, i.e. when KA is directly administered into the DG and epilepsy stages 4/5 become persistent, MC death might occur, in which case, a fall in Shh levels as well as an increase in neurogenesis could be expected60. The gene discussed is SMO; the disease is epilepsy.