SHH and neoplasm: The down regulated proteins were associated with genome instability (plasmamix Histon H3 (diMeth K9), Histone H3), the regulation of tumour growth (Androgen receptor, beta-catenin, Bim, Shh), DNA repair (PARP-1) and Notch signaling (Notch 1 intracellular domain (N1ICD), RBPSUH).