ALCAM and breast cancer: We compared them with previously reported breast cancer susceptibility loci that are identified from GWAS of multiple ethnicities, European, East Asian, African and Ashkenazi Jews, and found that nine loci identified from this study were previously reported while 3q13.11 (ALCAM) and 21q22.12 (CLIC6-RUNX1) are novel associated loci that surpassed genome-wide significance threshold (Table 1 and Fig. 1).