Among the previously reported loci, FGFR2 on chr10q26.13 and TOX3-CASC16 on chr16q12.1 are the two most significant associated breast cancer susceptible loci across different populations, followed by MAP3K1 on chr5q11.2 and CCDC170-ESR1 on chr6q25.1. The gene discussed is TOX3; the disease is breast cancer.