TIMP3 and Sorsby's fundus dystrophy: Point mutations in the C-terminal domain of TIMP3, that insert single cysteines into non-conserved sites (Tyr151Cys, Glu162Lys, Tyr174Cys, Tyr177Cys, Ser179Cys, Tyr182Cys, Gly189Cys, Gly190Cys, Tyr191Cys, Ser193Cys, Tyr195Cys, Tyr198Cys and Ser204Cys), are linked to Sorsby fundus Dystrophy (SFD), an inherited form of blindness37,38.