Through repressing STAT3 and RelA, PDLIM2 also blocks the transcription of various cancer-related genes, such as MDR1 and those involved in cell survival, proliferation, migration and invasion, thereby suppressing tumor growth and progression and sensitizing tumor cells to the cytotoxicity of chemotherapeutic drugs as well as of the basal and induced CTLs by anti-PD-1 and chemotherapeutic drugs. Here, STAT3 is linked to cancer.