PDLIM2 and neoplasm: Accordingly, PDLIM2 deletion from lung tumor cells diminished pulmonary T-cell activation in urethane mouse model of lung cancer, whereas re-expression of PDLIM2 in lung cancer cells increased tumor infiltration and activation of T cells and dendritic cells in syngeneic mouse model of lung cancer (Fig. 5d–g, Supplementary Fig. 6e–h).