Accordingly, more HDAC1 and in particular its phosphorylation form (p-HDAC1), but less acetylated histone H3K14 (H3K14Ac) and RNA polymerase II (Pol II), were found at the pdlim2 promoter in human lung cancer cells compared to normal lung epithelial cells (Fig. 2j). The gene discussed is HDAC1; the disease is lung cancer.