The aforementioned results indicated that HOXA11-AS can regulate the Wnt signaling pathway by modulating HOXA11 in HCC stem cells; therefore, the effects of HOXA11-AS on the self-renewal, invasion, and proliferation abilities of HCC stem cells mediated via the HOXA11/Wnt signaling pathway axis were studied. The gene discussed is HOXA11; the disease is hepatocellular carcinoma.