Polycystic kidney disease 1 (PKD1) and PKD2 are genes responsible for encoding polycystin 1 and polycystin 2 respectively, and loss-of-function of PKD1 and PKD2 genes can result in autosomal dominant polycystic kidney disease in subsequent generations [15]. This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.