Analysis of ALS specimens in the different cohorts of children aged 12–23 months showed that two immunisations with ETVAX alone (quarter or half dose) or half doses with 2·5 μg or 5·0 μg dmLT elicited significant increases in IgA antibodies in most vaccinees against all four vaccine colonisation factors and LTB (appendix p 12). This evidence concerns the gene CD79A and amyotrophic lateral sclerosis.