PNPLA2 and Hepatic steatosis: Mice with liver-specific ablation of ATGL, using the albumin-Cre promoter, are characterized by progressive development of hepatic steatosis that was exacerbated with age; accumulating 3-times more hepatic TG compared to a 2-fold increase of hepatic TG in the global knockout despite no change in overall body mass [15, 55].