These 12 genes have multiple roles and some areimplicated in synaptic function (e.g. SEPT7 [28] and CAPN1 [29]) and neurological diseases (e.g. AFF3 [30], NLGN4X [31], CAPN1 [32]and KIAA0319L [31]). This evidence concerns the gene CAPN1 and nervous system disorder.