The therapeutic claims for epileptic seizures are based thus on the probability of CBD and/or the related constituents in the cannabis affecting the endocannabinoid receptors (CB1/CB2) in the CNS and also in the periphery and thereby modulate the inflammatory status and neuronal network involved in the generation and/or spread of hyperexcitability and epileptic seizures [29]. The gene discussed is CNR1; the disease is Seizure.