SOCS3 and neoplasm: In glioblastoma cells, miR-221/222 are expressed at high levels and their downregulation results in a reduction of tumor invasion, migration, proliferation, and angiogenesis in association with decreased levels of MMP-2, MMP-9 and VEGF, and inactivation of the Janus kinase (JAK)/signal transducer of activation (STAT) pathway by the upregulation of SOCS3 (suppressor of cytokine signaling-3) [73].