For example, transcription factors of the MYC family (c-MYC and MYCN), which are associated with aggressive pediatric cancers such as medulloblastoma and neuroblastoma, bind to and activate the TERT promoter, resulting in high TERT mRNA levels of MYC- and MYCN-amplified tumors [113,120,121,122]. The gene discussed is MYCN; the disease is childhood malignant neoplasm.