TERT and hepatocellular carcinoma: In addition, genomic amplification of the TERT locus is a common mechanism of telomerase activation in some cancer types, particularly hepatocellular carcinoma (15%), lung adenocarcinoma (18%) and squamous cell carcinoma (25%), colorectal carcinoma (48%), and cervical intraepithelial neoplasms 2 and 3 (60% and 88%, respectively) (reviewed in [116]).