When NIR-PIT by the HER2 Affibody–IR700Dye conjugate is contemplated for brain metastases of HER2-overexpressing breast cancer, HER2 status can be examined by imaging [18,28], and NIR light can be irradiated directly during surgery or delivered by an optical fiber diffuser providing the NIR light directly to the tumor [29,30]. The gene discussed is ERBB2; the disease is breast cancer.