In general, GLP-1 RAs exert various beneficial effects in T2DM: enhancement of glucose-dependent insulin secretion, acceleration of β-cells proliferation and inhibition of β-cells apoptosis, inhibition of motility and gastric emptying, and a stimulation of the sensations of satiety and fullness by direct action on the central nervous system, with reduction in body weight [34,35,36,37]. Here, GLP1R is linked to type 2 diabetes mellitus.