Accordingly, knockdown of CALCB (which encodes CGRP2 and is activated by the Ewing sarcoma associated fusion protein EWSR1-FLI) or RAMP1 decreased growth of Ewing sarcoma cell lines in vitro and in a mouse xenograft model, and the small molecule CGRP antagonists MK-3207 and olcegepant reduced colony and sphere formation by Ewing sarcoma cells [6]. Here, FLII is linked to Ewing sarcoma.