Recently, a novel classification for colorectal cancer (CRC) was advocated as consensus molecular subtype (CMS) based on the following molecular features: CMS1 (microsatellite instability (MSI)-immune) as hypermutated, microsatellite unstable, and strong immune activation; CMS2 (canonical) as epithelial, marked WNT and MYC signaling activation; CMS3 (metabolic) as epithelial and evident metabolic dysregulation; and CMS4 (mesenchymal) as prominent TGF-β activation, stromal invasion, and angiogenesis [12]. This evidence concerns the gene TGFB1 and colorectal carcinoma.