In addition, inhibition of FLT3-ITD, but not BCR/ABL or JAK2-V617F, in the relevant cells was found to reduce activation specific phosphorylation of PDK1 in MV4-11, as well as primary FLT3-ITD-positive AML cells (Figure 3A,D,F). The gene discussed is BCR; the disease is acute myeloid leukemia.