In addition, inhibition of FLT3-ITD, but not BCR/ABL or JAK2-V617F, in the relevant cells was found to reduce activation specific phosphorylation of PDK1 in MV4-11, as well as primary FLT3-ITD-positive AML cells (Figure 3A,D,F). This evidence concerns the gene PDK1 and acute myeloid leukemia.