TSC2 and acute myeloid leukemia: It was confirmed that LJH685 reduced phosphorylation of TSC2 on S1798, as well as S6RP on S240/S244, inhibited the mTORC1 pathway as judged by decreases in phosphorylation of S6K on T389 and 4EBP1 on S65P, and reduced c-Myc expression also in primary FLT3-ITD-positive AML cells from one patient we could examine (Figure 5B,C).