On the other hand, Hospital M-A et al. [18] recently reported that inhibition of FLT3-ITD or KD of PIM2 decreased RSK2 expression in FLT3-ITD-positive AML cell line MOLM-14, although PIM2 inhibition decreased RSK2 expression in various AML cells regardless of their FLT3 mutational status, and its possible effect on RSK1 expression was not addressed. Here, RPS6KA1 is linked to acute myeloid leukemia.