PIM2 and acute myeloid leukemia: On the other hand, Hospital M-A et al. [18] recently reported that inhibition of FLT3-ITD or KD of PIM2 decreased RSK2 expression in FLT3-ITD-positive AML cell line MOLM-14, although PIM2 inhibition decreased RSK2 expression in various AML cells regardless of their FLT3 mutational status, and its possible effect on RSK1 expression was not addressed.