We have further elucidated the molecular mechanisms by which mainly RSK1 activates the mTORC1/S6K/4EBP1 and eIF4B in cooperation with the STAT5/PIM and PI3K/AKT pathways downstream of FLT3/ITD, and downregulates the pro-apoptotic Bcl-2 family members Bad and BIM to promote proliferation and prevent apoptosis in AML cells. Here, BCL2 is linked to acute myeloid leukemia.