Thus, RSK1 should play a central role in upregulation of translation by activating eIF4B, in addition to enhancing the eIF4F complex formation through phosphorylation of 4EBP1 and inducing S6RP phosphorylation in FLT3-ITD-positive AML cells (Figure 7). The gene discussed is RPS6KA1; the disease is acute myeloid leukemia.