Although we could not observe any effect of ERK or RSK inhibition on interaction of p85 with Gab2 or on its phosphorylation on Y452 in MV4-11 cells (Figure 4C,E), it should be noted that inhibition of RSKs remarkably enhanced activation of AKT in primary FLT3-ITD-positive AML cells we could examine (Figure 4B). This evidence concerns the gene FLT3 and acute myeloid leukemia.