Acute myeloid leukemia (AML), the most common acute leukemia, is a prime example with recurrent mutations in several genes encoding epigenetic enzymes (e.g., methylcytosine hydroxylase TET2, histone H3K27 methyltransferase EZH2, DNA methyltransferase DNMT3A) or repeated chromosomal translocations involving the H3K4 methyltransferase mixed lineage leukemia 1 (MLL1) [80,81,82]. Here, KMT2A is linked to acute myeloid leukemia.