TIM3, as one of the important immunity checkpoints, interacts with its ligand Gal‐924 could promote Tc1 cell9 apoptosis, CD8+T cell exhaustion,10, 11 malignant cell proliferation12 and MDSC proliferation.13 MDSCs, which are powerful cellular immunity suppressor, could badly inhibit the antitumour immune response mediated by the effector T cells and lead to tumour cells immunological surveillance escape.28, 29. The gene discussed is HAVCR2; the disease is neoplasm.