We also explored Notch1, eomesodermin (EOMES), phospho‐mTOR (p‐mTOR) and phospho‐AKT (p‐AKT) proteins, which are related to the function and proliferation of CD8+ T cells,15, 16 to verify that TIM3/Gal‐9 pathway might be involved in CD8+ T cells exhaustion induced by MDSCs in MDS patients. The gene discussed is AKT1; the disease is myelodysplastic syndrome.