Three systematic reviews and meta-analyses have already addressed in cancer patients the impact of ATM rs1801516 on normal tissue injuries after radiation therapy, of which two showed a significantly increased risk of acute toxicity (total patients: n = 1588) [20] and radiation-induced fibrosis (total patients: n = 2000) [21] respectively among carriers of minor allele of rs1801516, while one other found no significant association with radiation-induced adverse effects in general [22]. Here, ATM is linked to cancer.