Another miRNA, miR-520a binds to the 3' UTR of target genes including Microtubule Affinity Regulating Kinase 2 (MARK2), Estrogen Receptor 1 (ESR1) at early-stage cancer and Suppressor of Zeste 12 (SUZ12) during advance-stage and ESR1 during CRPC progression of prostate cancer (Table 1). This evidence concerns the gene ESR1 and Familial prostate cancer.