In the present study, we found that patients with tumor recurrence had higher expression levels of p-4EBP-1, eIF4E, and p-S6R and lower expression levels of p-PI3K and p-eIF4E than those without tumor recurrence, indicating that these signaling factors of the PI3K/AKT/mTOR pathway may worth investigating as the potential biomarkers for tumor recurrence prognosis. Here, EIF4E is linked to neoplasm.