It has been shown to exert neuroprotective effects against cerebral ischemic stroke both in animal models and stroke patients.37 Administration of RSG at the dose of 6 mg/kg 1 hour prior to MCAO could significantly reduce brain infarct at 48 hours after stroke.23 In order to explore the effect of RSG on the tPA‐induced HT after stroke, we injected RSG at the above‐mentioned dose and found that RSG significantly reduced hemorrhagic area, IgG extravasation, and tight junction protein degradation. This evidence concerns the gene PLAT and stroke disorder.