PLCB1 and myelodysplastic syndrome: Phospholipase C‐mediated nuclear inositide signaling is important in the pathogenesis of MDS.13 Deletion of the PLCB1 gene, which encodes another phospholipase C member, phospholipase C β1, is associated with leukemic transformation in MDS.14 Reduced PLCB1 expression is observed in MDS and associated with clinical outcomes.22 Although the functional difference between PLCG1 and PLCB1 is not clear, reduced expression of phospholipase C members may be involved in MDS molecular pathogenesis.