The PLCG1 gene encodes phospholipase C γ1, which has multiple roles in physiological and pathological intracellular pathways through nuclear inositide signaling and is involved in the development of human cancers including hematological malignancies.19, 20, 21 Reduced PLCG1 expression may result in the dysregulation of phospholipase C γ1‐mediated cellular process. The gene discussed is PLCG1; the disease is hematologic disorder.