UTRN and Duchenne muscular dystrophy: The first‐in‐class utrophin modulator ezutromid (formerly SMT C1100) 1 was discovered using a phenotypic screen for utrophin gene upregulation16, 17 and, after successful animal18 and human phase 1 trials,19, 20 progressed to an open‐label Phase 2 study in DMD patients (NCT02858362, Summit Therapeutics PLC).