KCs synthesize and secrete large amounts of TGF‐β1 in various factors, leading to hepatocyte injury.41 Our data demonstrated that CCL4‐induced mice had mild pro‐inflammatory response, and anti‐inflammatory factor TGF‐β1 was extremely high in CCL4‐induced mice, but was significantly reduced after TIM‐4 interference, so we focused on the relation between TIM‐4 and TGF‐β1. Here, TIMD4 is linked to dry eye syndrome.