To clarify the pathway, we overexpressed and blocked all aspects of the mentioned pathway and demonstrated that TIM‐4 interference in KCs inhibited Akt1‐mediated ROS production, resulting in the suppression of PINK1, Parkin and LC3‐II/I activation and the reduction of TGF‐β1 secretion during liver fibrosis. This evidence concerns the gene TIMD4 and Hepatic fibrosis.