Five patients (four males and one female, mean age 44.8 ± 7.8 years, range 36.4‐56.5) with severe AD (mean SCORAD 67.9 ± 11.4, range 52.2‐81.9) and highly elevated serum IgE levels (mean 5904 ± 5945 U/mL, range 1000‐15 600 IU/mL) were enrolled consecutively over a period of in total 6 months. The gene discussed is IGHE; the disease is Alzheimer disease.