The released Nrf2 enters into the nucleus and transcribes multiple antioxidative and detoxifying genes to protect the cells from oxidative damage.15, 16, 17, 18 The excessive activation of Keap1‐Nrf2 pathway is common in tumor cells and p62, a kind of autophagy adaptor, has been reported to be involved in this progression. The gene discussed is KEAP1; the disease is neoplasm.