Actually, a previous study has shown that mitochondrial membrane depolarization in peripheral lymphocytes is positively correlated with serum CRP levels and DAS28 values in patients with RA.15 DNM1L deficiency promoted mitochondrial membrane depolarization and decreased the levels of ROS and pro‐inflammatory COX‐2 and IL‐8 in RA FLSs, similar to that in synoviocytes.12 We also found that the ratio of DNM1L‐to‐MFN1 transcripts correlated with the level of serum anti‐CCP antibodies, DAS28 and ESR values in patients with RA. This evidence concerns the gene MFN1 and rheumatoid arthritis.