To examine whether the impact of DDIT4 expression on AML survival was independent, we constructed multivariate Cox proportional hazard models using multiple variables, including DDIT4 expression (high vs low), WBC count (≥15 vs <15 × 109/L), age (≥60 vs <60 years), BM blasts (≥70 vs <70%), PB blasts (≥20 vs <20%), NPM1 (mutated vs wild), DNMT3A (mutated vs wild), TET2 (mutated vs wild), TP53 (mutated vs wild) and FLT3‐ITD (positive vs negative) (Table 2). This evidence concerns the gene TET2 and acute myeloid leukemia.