Pinto et al observed a significant positive correlation between DDIT4 and NOTCH1 expression, and both of them tend to highly express in high‐risk AML patients.24 These results indicate that DDIT4 expression may explain some of the aggressive features of AML by involving in the above pathways, though the exact role of DDIT4 in leukaemogenesis requires further study. This evidence concerns the gene DDIT4 and acute myeloid leukemia.