Abnormally elevated DDIT4 expression has been found in various malignant tumours.10, 11 Though rapamycin‐derived mTOR inhibitors are powerful drugs in treating cancer, paradoxically, the naturally occurring DDIT4 seems to protect the cancer cells from apoptosis.10, 12, 13 Murine lymphocytes become more sensitive to dexamethasone‐induced cell death after DDIT4 knockdown.12 Additionally, DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways.14 The gene discussed is TP53; the disease is cancer.