Aberrant expression of LncRNAs such as Fendrr, Bvhta and KCNQ1OT1 may lead to congenital cardiovascular diseases and malformations.10 Besides, ANRIL, MIAT and MALAT1 have been demonstrated to play crucial roles in ischaemic heart disease.26 In addition, enforced expression of Mhrt ameliorated cardiac hypertrophy,27 while CHRF up‐regulation exacerbated cardiomyocyte hypertrophy.28 Moreover, lncRNAs might serve as new biomarkers of heart diseases. Here, KCNQ1OT1 is linked to cardiac hypertrophy.