Among 104 targets, seven genes [High Mobility Group Box 3 (HMGB3): P = 0.0013, Epithelial splicing regulatory protein 1 (ESRP1): P = 0.0013, GINS1: P = 0.0126, Tumor Protein D52 (TPD52): P = 0.0223, Serine/Arginine‐Rich Splicing Factor Kinase 1 (SRPK1): P = 0.0225, Vang‐like protein 1 (VANGL1): P = 0.0447, and Mago Homolog B (MAGOHB): P = 0.0471] were significantly associated with poor prognosis in patients with BrCa (Fig. 2). This evidence concerns the gene HMGB3 and invasive breast carcinoma.