Our discovery that TRPC7 is a nociceptive mechanoreceptor, together with our previous finding that TRPC7 has a role in UVB‐induced skin aging via increased ROS production (Hsu et al., 2015), is consistent with the previously reported links between nociceptive TRP receptors and aging (Buffenstein, 2008; Park et al., 2008; Riera et al., 2014; Seluanov et al., 2009). This evidence concerns the gene TRPC7 and skin aging.