Activated IGF1R is involved in cell growth and survival and influences an array of physiological and pathological conditions.29, 30, 31 For example, IGF1R inhibition is an escape mechanism in Ewing sarcoma and IGF1R inhibitors are candidate therapies for this disease.32 In this study, we found that IGF1R interacts with miR‐7025‐5p and that the down‐regulation of miR‐7025‐5p increases the IGF1R mRNA levels to promote osteogenic processes. This evidence concerns the gene IGF1R and Ewing sarcoma.