Two Western studies assessed soy supplement or soy isoflavone supplement, and neither of them found association of soy or soy isoflavone supplement with overall breast cancer risk [38, 39], though one study found that current soy isoflavone supplement was associated with reduced risk of estrogen receptor positive (ER+) breast cancer and increased risk of ER- breast cancer [39]. The gene discussed is ESR1; the disease is breast cancer.