To investigate whether St-ΔpGlux/pT-ClyA inhibits colon cancer growth by promoting increased production of IL-1β, we dynamically evaluated the efficacy of S.t-ΔpGlux/pT-ClyA for colon cancer treatment by MRI and explored the cellular origin of IL-1β in colon cancer treatment. The gene discussed is IL1B; the disease is malignant colon neoplasm.