The uptake of [111In]In-DTPA-trastuzumab-IRDye800CW after 48 h (> 80 %IA/g) in high HER2-expressing tumors and the tumor-to-blood ratios were relatively high in comparison with tumor uptake of other dual-labeled tracers [19, 20], which could indicate high detectability of the dual-labeled trastuzumab in breast tumors. This evidence concerns the gene ERBB2 and breast neoplasm.