This observation has been partially supported by human islet eQTL studies, where a few T2D-associated SNPs have been linked to genes other than their closest, including variants at CDC123 (linked to CAMK1D), ARAP1 (STARD10) and ZBED3 (PDE8B) [13••, 57, 58, 59•], and by CRISPR-mediated perturbations of diabetes-associated enhancers [13••]. This evidence concerns the gene PDE8B and type 2 diabetes mellitus.