In patients with stage II/III gastric cancer who were administrated adjuvant chemotherapy with S-1, although there was no significant difference in the 5-year OS between patients with high and low levels of FPGS mRNA expression, the 5-year OS in patients with the combination of high GGH mRNA and low FPGS mRNA expression levels in cancer tissue was significantly poorer than that in the other patients. Here, GGH is linked to gastric cancer.