FANCD2 and Fanconi anemia: In addition, DNA2 interacts with the inter-strand cross-link repair protein FANCD2 in U2OS cells, and knockdown of DNA2 suppressed the sensitivity of FANCD2-deficient cells to the DNA cross-linking agent cisplatin, suggesting a role for a putative DNA2/FANCD2 complex in the Fanconi anemia/BRCA pathway (126).