INS and Alzheimer disease: Employing two functionally different murine progenitor cell lines of AD progenitors (BMSCsadipo) and OB progenitors (BMSCsosteo), we observed a distinct metabolic gene signature of BMSCsadipo characterized by enrichment in genes of insulin signaling, autophagy, lipid metabolism, and glucose utilization, suggesting the presence of a hypermetabolic state.