In vitro treatment of BMSCsadipo and BMSCsosteo with PTH under adipogenic culture conditions for up to 10 days led to reduced AD differentiation in BMSCsadipo, as evidenced by the decreased number of Nile Red-positive mature ADs and reduced expression levels of adipocytic genes (Pparγ2 and Fsp27) (Fig. 5a, b). This evidence concerns the gene PTH and Alzheimer disease.