CD4 and Hepatosplenomegaly: Widespread homogenous lymphadenopathy may be a feature of both MAC and HL; however, lymphadenopathy is often massive in HL (> 3 cm diameter).5 Hepatosplenomegaly is commoner in MAC than in HL.5 HL tends to be seen with a CD4 count around 240 cells/μL4; in contrast, disseminated MAC is typically found with CD4 < 50 cells/μL.1